Variations in eosinophil chemokine responses: an investigation of CCR1 and CCR3 function, expression in atopy, and identification of a functional CCR1 promoter.

Identification of a Functional CCR1 CCR3 Function, Expression in Atopy, and Responses: An Investigation of CCR1 and Variations in Eosinophil Chemokine

CC chemokine receptors 1 and 3 are differentially regulated by IL-5 during maturation of eosinophilic HL-60 cells.

CC chemokine receptors 1 and 3 (CCR1 and CCR3) are expressed by eosinophils; however, factors regulating their expression and function have not previously been defined. Here we analyze chemokine receptor expression and function during eosinophil differentiation, using the eosinophilic cell line HL-60 clone 15 as a model system. RNA for CCR1, -3, -4, and -5 was not detectable in the parental cel...

Investigation of the Association between Rs13075270 and Rs13092160 Polymorphisms of CCR1 and CCR3 Genes with Behcet’s Disease

Introduction: Behcet's disease is an autoimmune disease that can affect various parts of the body. This disease manifests itself with skin, oral and ocular lesions. Although it is an idiopathic disease, various factors, including environmental and genetic factors, contribute to the onset of it. In this study, the association between two polymorphisms, namely rs13075270 and rs13092160 of CCR1 an...

Comparative Analysis of Expression of Chemokoine Receptors CXCR4, CXCR6, CCR1 and CX3CR in Human Adipose-Drived Mesenchymal Stem Cell with Valproic Acid

Introduction: Chemokine receptors are found on the surface of stem cells. There have been 19 distinct chemokine receptors described in mammals. Chemokines are major players in migration and homing. Therefore, changes in their levels or function can help us to increase the migratory potential of these cells. Valproic acid differs in structure from other drugs in common use. The way in which Va...

131 Expression of Chemokine Receptors CCR1, CCR3, CCR4, CCR5, CCR8 and CXCR3 in Human Nasal Polyps (NP); Comparison With NP From Allergic Patients With Aspirin Intolerance

eosinophils when compared with medium alone. Interestingly, blocking the activity of cysteinyl Leukotries using antagonists inhibited eosinophil-derived ASM proliferation. Conclusions: Eosinophils enhances the proliferation of ASM cells. This role of eosinophil does not seem to depend on ASM derived ECM proteins nor on Eosinophil derived TGF-b or TNF-a. Eosinophil seems to induce ASM proliferat...